Related Experiment Video

Updated: May 6, 2026

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
07:08

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

1.7K

Vitamin d and pancreatic cancer-an update

Kun-Chun Chiang1, Chun-Nan Yeh, Tai C Chen

  • 1Department of Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taiwan. taichen@bu.edu.

Cancers
|November 12, 2013
PubMed

Insights

Vitamin D and its analogs show potential in inhibiting pancreatic cancer cell growth. Further research into vitamin D

Area of Science:

  • Oncology
  • Endocrinology
  • Nutritional Science

Background:

  • Non-classical vitamin D actions (anti-proliferation, immune modulation) are key in cancer research.
  • Vitamin D's role in various cancer etiologies is increasingly recognized.
  • Pancreatic cancer cells exhibit sensitivity to vitamin D's inhibitory effects.

Purpose of the Study:

  • To review the therapeutic potential of vitamin D analogs in pancreatic cancer.
  • To explore the link between vitamin D status and pancreatic cancer.
  • To summarize biochemical and epidemiological evidence regarding vitamin D and pancreatic cancer.

Main Methods:

  • Literature review of epidemiological and biochemical studies.
  • Analysis of vitamin D metabolism and functions.
  • Examination of current pancreatic cancer therapies.

Main Results:

  • Biochemical data support vitamin D's inhibitory effect on pancreatic cancer cells.
  • Epidemiological evidence on vitamin D and pancreatic cancer remains under investigation.
  • Vitamin D analogs show promise as anticancer agents.

Conclusions:

  • Vitamin D analogs warrant further investigation for pancreatic cancer prevention and treatment.
  • Understanding vitamin D's role could lead to novel therapeutic strategies.
  • Combination therapies involving vitamin D analogs may enhance efficacy.

More Related Videos

Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma06:21

Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma

Published on: November 19, 2019

13.3K
Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic Cancer Mouse Models09:18

Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic Cancer Mouse Models

Published on: February 3, 2026

1.1K

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.6K
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
27
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
35
Connective Tissue Cell Types01:22

Connective Tissue Cell Types

Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
3.4K
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
6.5K
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
8.1K