"Kassinin" in mammals: the newest tachykinins

Until recently, substance P was widely believed to be the only mammalian representative of the tachykinin peptide family. In 1983, however, four independent groups using three different approaches reported that mammalian tissues also contain two novel tachykinins which resemble the amphibian tachykinin kassinin in both C-terminal sequence and pharmacology. Thus, the discovery of an active peptide in anuran skin has once again preceded the discovery of its mammalian analogs. While the discovery of the new peptides, substance K and neuromedin K, has clarified some issues in substance P research, it has raised some questions about others. With hindsight, it is clear that some of the activities once thought to be mediated by substance P may in fact be mediated by another mammalian tachykinin. Current knowledge of tachykinins and their receptors in mammals represents only a lower limit on the complexity of the system. This review summarizes recent progress in a rapidly developing field.