Related Experiment Video
Updated: May 6, 2026
03:42
Author Spotlight: Validating Cancer Therapy Responses with Desmoplastic Spheroid Models
Published on: September 27, 2024
1.9K
Growth factor mediated signaling in pancreatic pathogenesis
Debashis Nandy1, Debabrata Mukhopadhyay
1Department of Biochemistry and Molecular Biology, College of Medicine, Mayo Clinic, 200 First Street SW, Guggenheim 1321C, Rochester, MN 55905, USA. mukhopadhyay.debabrata@mayo.edu.
Cancers
|November 12, 2013
Summary
Growth factors like VEGF, IGF, and PDGF are crucial in pancreatic diseases, including pancreatitis and cancer. Understanding their signaling pathways is key for developing effective treatments for these conditions.
Area of Science:
- Gastroenterology
- Oncology
- Endocrinology
Background:
- The pancreas has exocrine and endocrine functions, with disorders affecting both.
- Exocrine disorders include pancreatitis, a risk factor for pancreatic cancer.
- Endocrine disorders like diabetes cause significant morbidity and mortality.
Purpose of the Study:
- To elucidate the role of growth factors in pancreatic pathophysiology.
- To understand the impact of growth factors on pancreatitis and pancreatic cancer.
- To explore the crosstalk between growth factor signaling pathways.
Main Methods:
- Review of literature on growth factors and pancreatic diseases.
- Analysis of the roles of specific growth factors: VEGF, IGF, PDGF, FGF, EGF, TGF.
- Discussion of signaling mechanisms and their involvement in pancreatitis and cancer.
Main Results:
- Growth factors and their receptors are critical in pancreatic pathogenesis.
- Specific growth factors influence pancreatitis and pancreatic cancer development.
- Interactions between growth factor signaling pathways are significant.
Conclusions:
- Understanding growth factor roles is essential for targeted pancreatic disease treatment.
- Further research into growth factor crosstalk can reveal novel therapeutic strategies.
- This chapter provides a comprehensive overview of growth factors in pancreatic health and disease.
More Related Videos
Related Concept Videos
01:27Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
2.8K
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
Insulin and C-peptide are...
2.8K
01:21Acute Pancreatitis II: Pathophysiology
49
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
49
01:26Type I Diabetes II: Pathophysiology
121
Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular...
121
01:16TGF - β Signaling Pathway
7.2K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.2K
01:21Chronic Pancreatitis II: Pathophysiology
35
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
35
01:24Chronic Pancreatitis I: Introduction
918
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
918