Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Postmortem neurochemistry in schizophrenia.

H S Bracha, J E Kleinman

    The Psychiatric Clinics of North America
    |March 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Postmortem studies in schizophrenia are advancing, despite replication challenges. New methods like autoradiography may improve understanding and treatment of this complex syndrome.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Fine mapping of PTSD GWAS reveals a role for amygdala <i>Foxp2</i> in regulation of fear and threat responses.

    bioRxiv : the preprint server for biology·2026
    Same author

    Genetic vulnerability to DUSP22 promoter hypermethylation is involved in the relation between in utero famine exposure and schizophrenia.

    NPJ schizophrenia·2018
    Same author

    Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder.

    Molecular psychiatry·2017
    Same author

    GAD1 alternative transcripts and DNA methylation in human prefrontal cortex and hippocampus in brain development, schizophrenia.

    Molecular psychiatry·2017
    Same author

    Investigating the neuroimmunogenic architecture of schizophrenia.

    Molecular psychiatry·2017
    Same author

    Altered expression of histamine signaling genes in autism spectrum disorder.

    Translational psychiatry·2017

    Area of Science:

    • Neuroscience
    • Psychiatry
    • Pathology

    Background:

    • Postmortem studies are experiencing a resurgence in schizophrenia research.
    • Despite numerous findings, challenges with replication and interpretation persist.
    • The postmortem approach remains a valuable tool for investigating schizophrenia.

    Purpose of the Study:

    • To review the current state and future directions of postmortem studies in schizophrenia.
    • To highlight the utility of postmortem analyses in testing neurochemical hypotheses.
    • To explore how novel techniques can enhance the understanding of schizophrenia.

    Main Methods:

    • Review of existing literature on postmortem schizophrenia research.
    • Discussion of traditional neurochemical analyses (catecholamines, indoleamines, neuropeptides).

    Related Experiment Videos

  • Introduction of advanced techniques: autoradiography and automated cell counting.

    • Main Results:

    • Postmortem studies have historically tested hypotheses related to neurotransmitters and neuropeptides.
    • New methodologies offer potential for more detailed and quantitative analyses.
    • Integration with premortem clinical data is crucial for enhanced insights.

    Conclusions:

    • Postmortem brain analysis remains a critical research avenue for schizophrenia.
    • Technological advancements promise to overcome previous limitations in replication and interpretation.
    • Combining postmortem findings with clinical data could lead to significant treatment breakthroughs.