Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

6.3K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.3K
The Tumor Microenvironment02:17

The Tumor Microenvironment

2.7K
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Taking a Swing at TIMP1-Armed Immunosuppressive Astrocytes Unleashes T cell Immunity against Brain Metastases.

Cancer discovery·2025
Same author

Natural killer cells are required for the recruitment of CD8+ T cells and the efficacy of immune checkpoint blockade in melanoma brain metastases.

Journal for immunotherapy of cancer·2024
Same author

Brain endothelial cells promote breast cancer cell extravasation to the brain via EGFR-DOCK4-RAC1 signalling.

Communications biology·2024
Same author

Immunotherapy in the context of immune-specialized environment of brain metastases.

Discovery immunology·2024
Same author

Biglycan and reduced glycolysis are associated with breast cancer cell dormancy in the brain.

Frontiers in oncology·2023
Same author

Do animal models of brain tumors replicate human peritumoral edema? a systematic literature search.

Journal of neuro-oncology·2023

Related Experiment Video

Updated: May 6, 2026

Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography
09:53

Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography

Published on: August 16, 2020

6.4K

Tumor microenvironment in the brain.

Mihaela Lorger1

  • 1Leeds Institute of Molecular Medicine, University of Leeds, St. James's University Hospital, Beckett Street, Leeds, LS9 7TF, UK. M.Lorger@leeds.ac.uk.

Cancers
|November 12, 2013
PubMed
Summary

Tumors involve diverse stromal cells in their microenvironment, influencing brain tumor growth. Understanding these interactions is key to developing new therapies for brain malignancies.

Area of Science:

  • Neuro-oncology
  • Cancer Biology
  • Immunology

Background:

  • Tumors comprise malignant cells and stromal cells forming the tumor microenvironment (TME).
  • TME composition varies by tumor site, with the brain having unique resident cells like microglia and astrocytes.
  • Brain tumors are infiltrated by bone marrow-derived cells, but their roles are poorly understood.

Purpose of the Study:

  • To review known interactions between brain tumors and stromal cells.
  • To discuss potential therapeutic strategies targeting the brain tumor microenvironment.

Main Methods:

  • Literature review of existing studies on brain tumor microenvironment.
  • Analysis of cellular interactions within the brain tumor context.

More Related Videos

A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies
10:13

A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies

Published on: November 7, 2015

10.7K
Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
05:45

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

9.2K

Related Experiment Videos

Last Updated: May 6, 2026

Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography
09:53

Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography

Published on: August 16, 2020

6.4K
A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies
10:13

A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies

Published on: November 7, 2015

10.7K
Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
05:45

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

9.2K

Main Results:

  • Stromal cells in the TME can either promote or inhibit tumor progression.
  • Specific brain-resident and bone marrow-derived cells play roles in brain malignancies.

Conclusions:

  • Understanding the brain tumor microenvironment is crucial for developing novel therapies.
  • Targeting TME interactions offers potential for improved brain tumor treatment.