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Does an increase in serum creatinine always reflect renal injury? The case of Stribild®

Vikram Arya1, Jeffry Florian, Kendall A Marcus

  • 1Division of Clinical Pharmacology 4, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.

Journal of Clinical Pharmacology
|November 12, 2013
PubMed

Insights

Single tablet, once-daily HIV treatment regimens, like Stribild®, improve adherence and reduce dosing errors for treatment-naïve adults. This fixed-dose combination offers a convenient option for managing HIV-1 infection.

Area of Science:

  • Antiviral Therapy
  • Pharmacology
  • Infectious Diseases

Background:

  • Single-tablet, once-daily HIV treatment regimens enhance patient convenience and adherence.
  • Fixed-dose combination (FDC) tablets aim to minimize dosing errors.
  • Stribild® is an approved FDC for treatment-naïve adult HIV-1 patients.

Purpose of the Study:

  • To provide an overview of Stribild® as a single-tablet, once-daily HIV treatment option.
  • To highlight the components and intended use of Stribild® in HIV-1 management.

Main Methods:

  • Review of Stribild®'s composition and approval status.
  • Description of the drug's active pharmaceutical ingredients and their mechanisms.

Main Results:

  • Stribild® is a four-drug FDC tablet.
  • It contains elvitegravir, cobicistat, emtricitabine (FTC), and tenofovir disoproxil fumarate (TDF).
  • Approved for treatment-naïve adult HIV-1 patients.

Conclusions:

  • Stribild® offers a convenient, once-daily dosing regimen for HIV-1 treatment.
  • The FDC formulation simplifies treatment and potentially improves patient outcomes.

Keywords:
MATE 1 transportersStribild®creatinine clearancerenal tubulopathy

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