The eukaryotic linear motif resource ELM: 10 years and counting

Area of Science:

• Molecular Biology
• Bioinformatics
• Systems Biology

Background:

• The Eukaryotic Linear Motif (ELM) resource has served the scientific community for over a decade.
• It functions as a central hub for collecting, classifying, and curating data on short linear motifs (SLiMs).

Purpose of the Study:

• To provide an updated overview of the ELM resource.
• To highlight its continued value as a freely accessible guide to the biology and function of linear motifs.

Main Methods:

• Manual curation of experimentally validated SLiM instances from scientific publications.
• Annotation of motif-mediated interactions in standard exchange formats.
• Integration with related biological resources like switches.elm.eu.org and KEGG pathways.

Main Results:

• The current ELM version encompasses approximately 200 distinct motif classes.
• It includes over 2400 experimentally validated SLiM instances.
• Detailed interaction data is available, linked to external pathway databases.

Conclusions:

• The ELM resource remains a vital, continuously updated database for SLiM research.
• It facilitates the study of motif-mediated interactions and their biological significance.
• The resource supports diverse research areas from molecular mechanisms to systems-level biology.