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Related Concept Videos

Antibody Structure01:10

Antibody Structure

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Antibody Structure01:10

Antibody Structure

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Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
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Antibody Structure and Classes01:25

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Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
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Antibody Actions01:26

Antibody Actions

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Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
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Gene Families01:57

Gene Families

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Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
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Protein Organization

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Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
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SAbDab: the structural antibody database.

James Dunbar1, Konrad Krawczyk, Jinwoo Leem

  • 1Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK, Informatics, UCB Pharma, 216 Bath Road, Slough SL1 4EN, UK and Roche Pharma Research & Early Development, Roche Diagnostics GmbH, 82377 Penzberg, Germany.

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Summary
This summary is machine-generated.

The Structural Antibody Database (SAbDab) offers a comprehensive, searchable collection of antibody structures. This resource facilitates research by providing detailed annotations and downloadable data for antibody analysis.

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Area of Science:

  • Structural biology
  • Immunology
  • Bioinformatics

Background:

  • Antibody structures are crucial for understanding immune responses and developing therapeutics.
  • A centralized, consistently annotated resource for antibody structural data is needed.

Purpose of the Study:

  • To present the Structural Antibody Database (SAbDab) as a comprehensive online resource for antibody structures.
  • To provide detailed annotations and facilitate data retrieval for researchers.

Main Methods:

  • Aggregating publicly available antibody structures.
  • Annotating structures with experimental, genetic, and binding affinity data.
  • Implementing search functionalities based on structural and annotation attributes.

Main Results:

  • SAbDab contains a large collection of consistently annotated antibody structures.
  • The database includes details on experimental conditions, gene information, chain pairings, antigen interactions, and binding affinities.
  • Users can query structures based on various attributes, including loop conformations and domain orientations.

Conclusions:

  • SAbDab serves as a valuable, accessible resource for the scientific community.
  • The database supports diverse research applications in antibody engineering and immunology.
  • Data and structures are available for download to facilitate further investigation.