AVIA: an interactive web-server for annotation, visualization and impact analysis of genomic variations

Area of Science:

• Genomics
• Bioinformatics
• Computational Biology

Background:

• Large-scale genome characterization generates vast amounts of data requiring efficient computational tools.
• Functional annotation and visualization of genomic variations present significant analytical challenges.
• Existing tools may not adequately address the integrated analysis of diverse genomic variations.

Purpose of the Study:

• To introduce AVIA (Annotation, Visualization and Impact Analysis), an interactive web-based tool.
• To facilitate the exploration and interpretation of large datasets of genomic variations.
• To assist in guiding and summarizing genomic experiments through data visualization and annotation.

Main Methods:

• Development of an interactive, web-based computational framework.
• Integration of annotation, visualization, and impact analysis functionalities.
• User-friendly interface for uploading and analyzing single nucleotide variations and insertion/deletions.

Main Results:

• AVIA provides interactive exploration of genomic variations.
• The tool enables functional annotation within a whole-genome or multi-genome context.
• Annotation summaries, plots, and tables are downloadable via email link.

Conclusions:

• AVIA offers a comprehensive solution for analyzing and visualizing large-scale genomic variation data.
• The tool enhances the interpretation of genomic experiments.
• Web-based accessibility promotes widespread adoption in genomic research.