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Related Experiment Videos

Bradykinin accelerates mucociliary activity in rabbit maxillary sinus.

S Lindberg, U Mercke

    Acta Oto-Laryngologica
    |January 1, 1986
    PubMed
    Summary

    Bradykinin enhances mucociliary (m.c.) activity in rabbit sinuses dose-dependently. This effect involves substance P and acetylcholine, indicating a dual mechanism in airway reflexes.

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    Area of Science:

    • Respiratory Physiology
    • Neuropharmacology

    Background:

    • Mucociliary activity is crucial for airway clearance.
    • Bradykinin's role in sinus mucociliary function is not fully understood.

    Purpose of the Study:

    • To investigate the in vivo effect of bradykinin on rabbit maxillary sinus mucociliary activity.
    • To elucidate the underlying mechanisms of bradykinin-induced mucociliary acceleration.

    Main Methods:

    • Administration of bradykinin (0.01-10.0 µg/kg) via the maxillary artery in rabbits.
    • Non-invasive photoelectric technique for recording mucociliary activity.
    • Assessment of drug interactions with indomethacin, substance P antagonist, and atropine.

    Main Results:

    • Bradykinin dose-dependently accelerated mucociliary activity (0.05-10.0 µg/kg).
    • Bradykinin's effect was resistant to indomethacin but weakened by a substance P antagonist.
    • Atropine suppressed the initial bradykinin effect, suggesting a dual mechanism.

    Conclusions:

    • Bradykinin accelerates sinus mucociliary activity through a dual mechanism involving substance P and acetylcholine.
    • Bradykinin likely activates a reflex arc involving afferent substance P neurons and efferent parasympathetic neurons.

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