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Updated: May 6, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

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Emerging roles of orphan nuclear receptors in cancer

Sung Hee Baek1, Keun Il Kim

  • 1School of Biological Sciences, Creative Research Initiative Center for Chromatin Dynamics, Seoul National University, Seoul 151-742, South Korea;

Annual Review of Physiology
|November 13, 2013
PubMed

Insights

Orphan nuclear receptors are implicated in human cancers, but their roles in tumor progression and as drug targets require further study. This review explores their involvement and therapeutic potential in various cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Endocrinology

Background:

  • Orphan nuclear receptors (ONRs) are increasingly recognized as significant factors in human cancers.
  • Their amplification and prognostic value in certain cancers are supported by growing evidence.
  • However, their precise functions in tumor development and suitability as therapeutic targets remain incompletely understood.

Purpose of the Study:

  • To review recent advancements in understanding the direct and indirect roles of ONRs in cancer.
  • To evaluate the therapeutic potential of targeting ONRs across diverse human malignancies.
  • To compare the functions of ONRs in cancer with those of estrogen and androgen receptors in hormone-dependent cancers.

Main Methods:

  • Literature review of recent studies on orphan nuclear receptors and cancer.
  • Analysis of evidence regarding the involvement of ONRs in tumor progression.
  • Examination of data on the therapeutic efficacy of targeting ONRs.

Main Results:

  • Orphan nuclear receptors play multifaceted roles in the progression of various human cancers.
  • Targeting specific ONRs shows promise as a therapeutic strategy for certain cancers.
  • The mechanisms of ONRs in cancer differ from those of established hormone receptors.

Conclusions:

  • Orphan nuclear receptors are critical players in human oncogenesis with significant therapeutic implications.
  • Further research into ONRs will likely uncover novel strategies for cancer treatment.
  • Understanding the distinct roles of ONRs compared to estrogen and androgen receptors is key for targeted therapies.

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