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Canine oral mucosal mast cell tumours
J W Elliott1, P Cripps1, L Blackwood2
1Department of Veterinary Clinical Science, Liverpool University, Liverpool, UK.
Veterinary and Comparative Oncology
|November 13, 2013
Summary
Oral mucosal mast cell tumors (MCTs) in dogs frequently metastasize to lymph nodes, indicating a poor prognosis. Local tumor control is crucial for improved outcomes in these aggressive canine cancers.
Area of Science:
- Veterinary Oncology
- Canine Pathology
Background:
- Mast cell tumors (MCTs) are common in dogs, typically affecting the skin.
- Oral mucosal MCTs are rare but exhibit a more aggressive clinical behavior than cutaneous MCTs.
Purpose of the Study:
- To investigate the incidence of lymph node metastasis in oral mucosal MCTs in dogs.
- To evaluate the prognostic significance of lymph node metastasis and mitotic index (MI) in canine oral MCTs.
Main Methods:
- Retrospective study of 33 dogs with oral mucosal MCTs.
- Analysis of lymph node metastasis at diagnosis.
- Assessment of mitotic index (MI) as a prognostic factor.
Main Results:
- High incidence of lymph node metastasis (55%) at diagnosis in oral mucosal MCTs.
- Lymph node metastasis and mitotic index were identified as significant negative prognostic factors.
- Adequate local tumor control correlated with improved outcomes for affected dogs.
Conclusions:
- Oral mucosal MCTs in dogs have a high rate of metastasis and a poor prognosis.
- Mitotic index and nodal status are critical prognostic indicators.
- Effective local treatment can lead to prolonged survival, even with metastatic disease.
