Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tissues01:25

Tissues

63.9K
Tissues are a group of cells that share a common embryonic origin. Microscopic observation reveals that the cells in a tissue share morphological features and are arranged in an orderly pattern to perform specific functions. From an evolutionary perspective, tissues appear in more complex organisms. Although there are many types of cells in the human body, they are organized into four broad categories of tissues: epithelial, connective, muscle, and nervous. Each of these categories is...
63.9K
Tissues01:18

Tissues

70.2K
Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.
70.2K
The Tumor Microenvironment02:17

The Tumor Microenvironment

6.3K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Race-based differences in serum biomarkers for cancer-associated cachexia in a diverse cohort of patients with pancreatic ductal adenocarcinoma.

Communications medicine·2025
Same author

The Impact of Edema on Skeletal Muscle Changes among Patients with Pancreatic Ductal Adenocarcinoma.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·2025
Same author

Systematic review of long-term effectiveness of endoscopic gastrojejunostomy in patients presenting with gastric outlet obstruction from periampullary malignancies.

Surgical endoscopy·2024
Same author

Comparison between transpapillary versus transmural endoscopic ultrasound-guided decompression for biliary obstruction: a meta-analysis.

HPB : the official journal of the International Hepato Pancreato Biliary Association·2023
Same author

Benefits of EUS-guided gastroenterostomy over surgical gastrojejunostomy in the palliation of malignant gastric outlet obstruction: a large multicenter experience.

Gastrointestinal endoscopy·2023
Same author

The Florida Pancreas Collaborative Next-Generation Biobank: Infrastructure to Reduce Disparities and Improve Survival for a Diverse Cohort of Patients with Pancreatic Cancer.

Cancers·2021

Related Experiment Video

Updated: May 6, 2026

Optimization of Breast Biopsy and Mastectomy Sample Collection Procedures for Biobanking, Personalized Medicine, and Research Applications
06:42

Optimization of Breast Biopsy and Mastectomy Sample Collection Procedures for Biobanking, Personalized Medicine, and Research Applications

Published on: September 2, 2025

790

Beyond cytology: why and when does the oncologist require core tissue?

Sebastian G de la Fuente1, J Pablo Arnoletti

  • 1Florida Hospital Orlando, University of Central Florida, Orlando, FL, USA.

Gastrointestinal Endoscopy Clinics of North America
|November 13, 2013
PubMed
Summary

Oncologists need more tissue and histologic sections from fine-needle aspiration (FNA) specimens for better tumor diagnosis and molecular analysis. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) and endoscopic ultrasound-guided core needle biopsy (EUS-CNB) are complementary tools for improved cancer diagnostics.

Keywords:
Core needle biopsy (CNB)Endoscopic ultrasound (EUS)Fine-needle aspiration (FNA)Gastrointestinal stromal tumor (GIST)LymphomaPancreatic cancer

More Related Videos

Simple and Rapid Method to Obtain High-quality Tumor DNA from Clinical-pathological Specimens Using Touch Imprint Cytology
11:20

Simple and Rapid Method to Obtain High-quality Tumor DNA from Clinical-pathological Specimens Using Touch Imprint Cytology

Published on: March 21, 2018

10.4K
Establishment of a Clinic-based Biorepository
07:50

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

6.2K

Related Experiment Videos

Last Updated: May 6, 2026

Optimization of Breast Biopsy and Mastectomy Sample Collection Procedures for Biobanking, Personalized Medicine, and Research Applications
06:42

Optimization of Breast Biopsy and Mastectomy Sample Collection Procedures for Biobanking, Personalized Medicine, and Research Applications

Published on: September 2, 2025

790
Simple and Rapid Method to Obtain High-quality Tumor DNA from Clinical-pathological Specimens Using Touch Imprint Cytology
11:20

Simple and Rapid Method to Obtain High-quality Tumor DNA from Clinical-pathological Specimens Using Touch Imprint Cytology

Published on: March 21, 2018

10.4K
Establishment of a Clinic-based Biorepository
07:50

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

6.2K

Area of Science:

  • Gastroenterology
  • Oncology
  • Pathology

Background:

  • Cytopathology from fine-needle aspiration (FNA) specimens can be insufficient for comprehensive tumor analysis.
  • Oncologists require additional tissue for improved diagnostic accuracy and molecular characterization of tumors.

Purpose of the Study:

  • To highlight the necessity of obtaining additional tissue and histologic sections alongside cytopathology from FNA specimens.
  • To emphasize the complementary roles of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) and endoscopic ultrasound-guided core needle biopsy (EUS-CNB) in oncology.

Main Methods:

  • Review of current oncologic diagnostic procedures.
  • Comparative analysis of FNA and EUS-CNB techniques.

Main Results:

  • Two primary reasons for requiring additional tissue: enhanced diagnostic accuracy and molecular profiling of tumors.
  • EUS-FNA and EUS-CNB are not mutually exclusive but supplementary diagnostic procedures.

Conclusions:

  • Both EUS-FNA and EUS-CNB should be integrated as essential tools in endoscopic practice.
  • Combining these techniques improves the diagnostic yield and molecular characterization of tumors, aiding oncologists in treatment decisions.