Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbial Interactions: Parasitism01:22

Microbial Interactions: Parasitism

116
Parasitism is a form of microbial interaction in which parasitic microbes exploit a host organism for nutrients and shelter, often at the host's expense. Unlike mutualistic relationships, where both organisms benefit, parasitism benefits only the parasite and harms the host.Classification of ParasitesMicrobial parasites are broadly classified based on their location relative to the host.Ectoparasites remain on the host’s surface, such as the skin or outer tissues, drawing nutrients...
116
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

129
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
129
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

865
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
865
Genomics02:02

Genomics

35.6K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
35.6K
Evolution of Microbial Genome01:08

Evolution of Microbial Genome

116
Microbial genome evolution is a highly dynamic process shaped by continual gene gain and loss across species and strains. This genomic flexibility allows microorganisms to adapt rapidly to environmental pressures and interactions with other organisms. Central to understanding this diversity is the distinction between the core and pan genomes.The core genome comprises the genes shared by all sampled strains of a species, representing essential functions needed for fundamental cellular processes.
116

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Uncovering the isoform-resolution kinetic landscape of nonsense-mediated mRNA decay with EZbakR.

Genome biology·2026
Same author

Chemoselective Halogenation of Premarineosin A for Next-Generation Antimalarial Development.

bioRxiv : the preprint server for biology·2026
Same author

A fission yeast-based platform for nematode PDE inhibitor discovery.

Cellular signalling·2026
Same author

Metabolic engineering and late-stage functionalization expand the chemical space of the antimalarial premarineosin A.

Communications chemistry·2025
Same author

Cyclic peptides as ligands for competition binding assays.

Methods in enzymology·2025
Same author

Pharmacologic activation of Δ133p53α reduces cellular senescence in progeria patients-derived cells.

Aging pathobiology and therapeutics·2025

Related Experiment Video

Updated: May 6, 2026

Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-γ-Dependent Cell Autonomous Immunity
11:21

Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-γ-Dependent Cell Autonomous Immunity

Published on: March 12, 2015

9.6K

Chemical genomics for studying parasite gene function and interaction.

Jian Li1, Jing Yuan, Ken Chih-Chien Cheng

  • 1State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, P.R. China.

Trends in Parasitology
|November 13, 2013
PubMed
Summary

New technologies enable small molecules to advance gene studies. These methods aid in identifying drug targets, understanding gene function, and developing new anti-parasitic drugs.

Keywords:
gene functiongeneticsgenomicshigh-throughput screening

More Related Videos

Genetic Manipulation in Δku80 Strains for Functional Genomic Analysis of Toxoplasma gondii
09:52

Genetic Manipulation in Δku80 Strains for Functional Genomic Analysis of Toxoplasma gondii

Published on: July 12, 2013

18.0K
CRISPR/Cas9 Gene Editing to Make Conditional Mutants of Human Malaria Parasite P. falciparum
09:25

CRISPR/Cas9 Gene Editing to Make Conditional Mutants of Human Malaria Parasite P. falciparum

Published on: September 18, 2018

9.7K

Related Experiment Videos

Last Updated: May 6, 2026

Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-γ-Dependent Cell Autonomous Immunity
11:21

Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-γ-Dependent Cell Autonomous Immunity

Published on: March 12, 2015

9.6K
Genetic Manipulation in Δku80 Strains for Functional Genomic Analysis of Toxoplasma gondii
09:52

Genetic Manipulation in Δku80 Strains for Functional Genomic Analysis of Toxoplasma gondii

Published on: July 12, 2013

18.0K
CRISPR/Cas9 Gene Editing to Make Conditional Mutants of Human Malaria Parasite P. falciparum
09:25

CRISPR/Cas9 Gene Editing to Make Conditional Mutants of Human Malaria Parasite P. falciparum

Published on: September 18, 2018

9.7K

Area of Science:

  • Genomics
  • Pharmacology
  • Molecular Biology

Background:

  • Advancements in high-throughput screening and genome-wide technologies are crucial for biological research.
  • Small molecules are increasingly utilized to investigate gene expression, interactions, and functions.

Purpose of the Study:

  • To review recent progress in drug target identification and phenotype characterization.
  • To highlight the integration of small-molecule screening with genome-wide analyses.
  • To discuss applications in discovering anti-parasitic drugs and inferring gene function.

Main Methods:

  • High-throughput screening of small-molecule libraries.
  • Genome-wide methods including whole-genome sequencing and gene expression analysis.
  • Genome-wide association studies (GWAS).

Main Results:

  • Combined approaches facilitate drug target identification.
  • Phenotype characterization is enhanced through integrated screening and genomic data.
  • These methods aid in discovering novel anti-parasitic therapeutics.

Conclusions:

  • The synergy between small molecules and genome-wide approaches offers powerful tools for biological discovery.
  • These integrated strategies are vital for identifying drug targets and understanding gene function.
  • Future research can leverage these techniques for developing new treatments against infectious diseases.