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A Novel Scalp Acupuncture-based Method to Target the Hand Motor Hotspot for Non-invasive Brain Stimulation
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Acupuncture and neurotrophin modulation.

Marzia Soligo1, Stefania Lucia Nori, Virginia Protto

  • 1Institute of Translational Pharmacology, National Research Council (CNR), Rome, Italy.

International Review of Neurobiology
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Acupuncture may improve nerve function and aid recovery from nerve injuries by influencing neurotrophins, which are key proteins for nerve health. This review explores the scientific evidence linking acupuncture to these beneficial effects on the nervous system.

Keywords:
AcupunctureBDNFNGFNT-3NT-4NeurotrophinsPhysical therapySortilinTrkp75(NTR)

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Area of Science:

  • Neuroscience
  • Integrative Medicine
  • Pharmacology

Background:

  • Acupuncture's therapeutic effects are increasingly explained by neurophysiological mechanisms.
  • Key among these is the regulation of neurotransmitters, neurohormones, and neuromodulators.
  • Neurotrophins play a crucial role in nerve health and function.

Purpose of the Study:

  • To review a decade of research on the relationship between acupuncture and neurotrophins.
  • To explore the neurophysiological basis of acupuncture's effects.
  • To understand acupuncture's impact on the neurotrophic milieu in various diseases.

Main Methods:

  • Systematic review of scientific literature.
  • Analysis of studies investigating acupuncture's effects on neurotrophin expression and activity.
  • Correlation of findings with known neurophysiological regulatory mechanisms.

Main Results:

  • Evidence suggests acupuncture influences neurotrophin expression and activity.
  • This modulation is linked to acupuncture's efficacy in conditions like neuropathic pain and nerve injury.
  • Acupuncture's effects on gonadal functions may also involve neurotrophic regulation.

Conclusions:

  • Acupuncture's ability to regulate neural physiology is closely tied to its effects on the neurotrophic system.
  • Neurotrophin regulation represents a significant mechanism underlying acupuncture's therapeutic benefits.
  • Further research can elucidate the precise pathways for clinical applications.