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Related Experiment Videos

Mouse alpha 1-protease inhibitor is not an acute phase reactant.

H Baumann, J J Latimer, M D Glibetic

    Archives of Biochemistry and Biophysics
    |April 1, 1986
    PubMed
    Summary

    Mouse alpha 1-protease inhibitor (alpha 1-PI) is not an acute phase reactant, unlike in humans. Systemic injury increased contrapsin levels but not alpha 1-PI, indicating distinct roles in mouse inflammation.

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    Area of Science:

    • Biochemistry
    • Immunology
    • Protease Inhibitor Research

    Background:

    • Mouse plasma contains alpha 1-protease inhibitor (alpha 1-PI) and contrapsin, both high-affinity trypsin inhibitors.
    • Alpha 1-PI is an acute phase reactant in humans, but its role in mice is unclear.

    Purpose of the Study:

    • To investigate whether mouse alpha 1-protease inhibitor (alpha 1-PI) functions as an acute phase reactant.
    • To compare the response of alpha 1-PI and contrapsin to systemic inflammation.

    Main Methods:

    • Inducing systemic inflammation using turpentine in mice.
    • Measuring plasma concentrations of alpha 1-PI and contrapsin.
    • Analyzing hepatic alpha 1-PI mRNA levels via Northern blot hybridization.

    Main Results:

    • Turpentine-induced inflammation significantly increased contrapsin plasma levels by 50%.
    • Plasma concentrations of alpha 1-PI remained unchanged following systemic injury.
    • Hepatic alpha 1-PI mRNA levels were not significantly affected by the acute phase reaction.

    Conclusions:

    • Mouse alpha 1-protease inhibitor (alpha 1-PI) is not an acute phase reactant.
    • Contrapsin levels increase during acute inflammation in mice, suggesting a distinct role.
    • Findings contrast with human alpha 1-PI, highlighting species-specific differences in acute phase responses.

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