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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

33.7K

Interferon-dependent IL-10 production by Tregs limits tumor Th17 inflammation

C Andrew Stewart, Hannah Metheny, Noriho Iida

    The Journal of Clinical Investigation
    |November 13, 2013
    PubMed
    Summary

    Interleukin-10 (IL-10) produced by regulatory T cells (Tregs) restrains Th17 inflammation in the tumor microenvironment. Type I interferons (IFN) are crucial for this Treg-mediated suppression, impacting cancer immunotherapy strategies.

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