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Related Concept Videos

Master Transcription Regulators02:23

Master Transcription Regulators

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Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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General Transcription Factors01:30

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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Transcription Factors02:16

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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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RNA Polymerase II Accessory Proteins02:36

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Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
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HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
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Th9 cell development requires a BATF-regulated transcriptional network.

Rukhsana Jabeen, Ritobrata Goswami, Olufolakemi Awe

    The Journal of Clinical Investigation
    |November 13, 2013
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    Summary

    The transcription factor BATF (B cell, activating transcription factor–like) is crucial for T helper 9 cell function and IL-9 production. Its role in allergic inflammation highlights its potential as a therapeutic target.

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    Area of Science:

    • Immunology
    • Molecular Biology
    • Allergy Research

    Background:

    • T helper 9 (Th9) cells produce IL-9 and are implicated in allergic inflammation.
    • The specific transcriptional signature of Th9 cells remains largely uncharacterized.
    • Understanding Th9 cell regulation is key to addressing allergic diseases.

    Purpose of the Study:

    • To identify the characteristic transcriptional signature of Th9 cells.
    • To elucidate the regulatory network governing Th9-enriched genes.
    • To investigate the role of the transcription factor BATF in Th9 cell function and allergic inflammation.

    Main Methods:

    • Microarray analysis to compare gene expression in Th9 cells versus other T helper subsets.
    • Functional assays in human and mouse T cells to assess the role of BATF.
    • Analysis of BATF expression in Th9 cells from atopic infants.

    Main Results:

    • Microarray analysis identified a unique transcriptional signature for Th9 cells.
    • The transcription factor BATF (B cell, activating transcription factor–like) was enriched in Th9 cells and essential for IL-9 production.
    • BATF deficiency reduced the capacity of T cells to promote allergic inflammation.
    • Increased BATF expression was observed in Th9 cells from atopic infants.

    Conclusions:

    • BATF is a central regulator of the Th9 cell phenotype.
    • BATF plays a significant role in the development of allergic inflammation.
    • Targeting BATF may offer a novel therapeutic strategy for allergic diseases.