Kissing gastric ulcers causing acute pancreatitis and portal biliopathy: what's the link?
Related Experiment Video
Updated: May 6, 2026

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
Published on: April 1, 2022
Alexandre Mensier1, Farid Bounoua, Gabriel Beretvas
1Department of Digestive Surgery. Hospital of Armentières. Armentières, France. titanium595@hotmail.com.
Context:
Acute pancreatitis is often caused by acute alcoholic intoxication or biliary stone migration. Other etiologies are less frequent.
Case Report:
We report an exceptional case of kissing ulcer as the cause of an acute pancreatitis due to the perforation of the posterior ulcus into the pancreas. More remarkable is the association of a left portal branch thrombosis and a portal biliopathy.
Conclusion:
We describe a case of acute pancreatitis of unusual origin, associated with an equally uncommon pathology which is portal cavernoma. A literature review is then exposed to try to ascertain if there is a connection between these two entities.
Related Concept Videos
Pathophysiology of Peptic Ulcer Disease: Injurious Factors
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
Peptic Ulcer Disease I: Introduction
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
Peptic Ulcer Disease I: Introduction
Peptic Ulcer
Peptic Ulcer Disease II: Pathophysiology
Peptic Ulcer Disease II: Pathophysiology
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.

