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Updated: May 6, 2026

Author Spotlight: Generation of Patient-Derived Podocytes from Skin Biopsies

Author Spotlight: Generation of Patient-Derived Podocytes from Skin Biopsies

Published on: May 26, 2023

Basic research: Podocyte progenitors and ectopic podocytes.

Laura Lasagni¹, Paola Romagnani

¹Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies (DENOTHE), University of Florence, Viale Morgagni 85, Florence 50134, Italy.

Nature Reviews. Nephrology

|November 13, 2013

Summary

Two parietal podocyte types in Bowman capsule are reclassified. Research shows they are distinct cell types: podocyte progenitors and ectopic podocytes, with differing clinical relevance.

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Area of Science:

Nephrology
Cell Biology
Histology

Background:

The Bowman capsule contains parietal cells, traditionally considered epithelial. Previous studies identified two parietal podocyte populations based on marker expression.
These populations were ambiguously defined, lacking clear distinction and clinical correlation.

Purpose of the Study:

To clarify the identity and distinct roles of the two previously described parietal podocyte populations.
To differentiate between podocyte progenitors and ectopic podocytes within the Bowman capsule.

Main Methods:

Immunohistochemistry and immunofluorescence staining of kidney tissue.
Analysis of cell marker expression patterns (podocyte and parietal epithelial cell markers).
Comparative analysis of distinct cell populations.

Main Results:

One population coexpresses podocyte and parietal epithelial cell markers, identified as podocyte progenitors.
The second population expresses only podocyte markers, identified as ectopic podocytes.
These two cell types exhibit distinct characteristics and potential clinical implications.

Conclusions:

The previously described parietal podocyte populations are not homogeneous.
These findings distinguish podocyte progenitors from ectopic podocytes, offering new insights into kidney physiology and pathology.
Understanding these distinct cell types is crucial for diagnosing and treating kidney diseases.