Related Experiment Video
Updated: May 6, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Bilateral squamous cell carcinoma of the lacrimal sac
Nickisa Hodgson1, Katherine Whipple, Jonathan H Lin
1*Division of Ophthalmic Plastic and Reconstructive Surgery, Shiley Eye Center, †Departments of Pathology and Ophthalmology, VA San Diego Healthcare System, and ‡Division of Otolaryngology-Head and Neck Surgery, University of California, San Diego, California, U.S.A.
Abstract:
A 42-year-old man presented with right-sided epiphora, a fleshy lesion emanating from the right inferior punctum and a painless mass below the medial canthal tendon. Biopsy of the lacrimal sac mass disclosed papillary squamous cell carcinoma in situ. The patient underwent wide local excision with clear surgical margins and remained disease free until 28 months later when he returned with hemorrhagic epiphora of the OS and fullness overlying the left lacrimal sac. Biopsy confirmed papillary squamous cell carcinoma in situ. He underwent similar excision and has remained disease free for 6 months. To the best of the authors' knowledge, this is the first report of bilateral squamous cell carcinoma of the lacrimal sac.

