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Is microalbuminuria a risk factor for hypertension in children with solitary kidney?

Ayoub Shirzai1, Nurdan Yildiz, Nese Biyikli

  • 1Department of Pediatric Nephrology, Marmara University Medical Faculty, Istanbul, Turkey.

Pediatric Nephrology (Berlin, Germany)
|November 13, 2013
PubMed

Insights

Children with a solitary kidney (SK) show increased 24-hour urinary microalbumin excretion over time. Long-term monitoring is crucial for early detection of kidney function decline and preventing future organ damage.

Area of Science:

  • Pediatric Nephrology
  • Renal Physiology
  • Diagnostic Biomarkers

Background:

  • Children with solitary kidney (SK) may face long-term renal health risks.
  • Assessing kidney function in SK requires understanding correlations between blood pressure and urinary markers.
  • Existing research lacks comprehensive analysis of these correlations in pediatric SK populations.

Purpose of the Study:

  • To analyze correlations between ambulatory blood pressure measurements (ABPM) and serum/urinary biomarkers in children with SK.
  • To compare these correlations with those in healthy children.
  • To identify potential long-term renal function changes in children with SK.

Main Methods:

  • Studied 50 children with solitary kidney (SK) and 25 healthy controls.
  • Measured ABPM, serum cystatin C (Cys C), serum creatinine (Cr), and 24-hour urinary microalbumin (MA) and β2-microglobulin (β2-MG).
  • Recorded clinical data, imaging results, and excluded patients with specific conditions like Wilms' tumor.

Main Results:

  • Serum Cys C, Cr, and urinary β2-MG levels were similar between SK and control groups.
  • 24-hour urinary MA excretion was significantly higher in SK patients with over 5 years of follow-up (p=0.01).
  • No significant correlation was found between ABPM parameters and the measured biomarkers in either group.

Conclusions:

  • Children with SK exhibit increased long-term 24-hour urinary MA excretion.
  • Prolonged follow-up is necessary for early detection of renal function deterioration in SK.
  • Early intervention can help prevent end-organ damage in children with solitary kidneys.
Abstract

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