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Updated: Feb 12, 2026
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Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
Published on: October 6, 2022
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[Neuropathic pain: pathophysiology, assessment, and therapy]
1Neurologische Klinik, Universitätsklinikum Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Deutschland, sommer@uni-wuerzburg.de.
Schmerz (Berlin, Germany)
|November 13, 2013
Summary
Neuropathic pain, stemming from somatosensory system damage, involves complex sensitization. Recent advances improve understanding, assessment, and offer more therapeutic options like antidepressants and anticonvulsants.
Area of Science:
- Neurology
- Pain Medicine
- Neuroscience
Context:
- Neuropathic pain arises from somatosensory system lesions.
- Characterized by burning, shooting pain, hyperalgesia, and allodynia.
- Pathophysiology involves peripheral and central sensitization.
Purpose:
- To review the current understanding of neuropathic pain mechanisms.
- To highlight advancements in assessment methods for nociceptor dysfunction.
- To discuss the expanding therapeutic landscape for neuropathic pain.
Summary:
- Molecular mechanisms of neuropathic pain have seen exponential growth in research.
- Challenges remain in identifying individual mechanisms and forming a comprehensive concept.
- Improved assessment tools for nociceptor dysfunction are now available.
Impact:
- Increased knowledge of neuropathic pain pathophysiology.
- Enhanced diagnostic capabilities for somatosensory system dysfunction.
- Expanded therapeutic options, including antidepressants, anticonvulsants, opioids, and topical agents, supported by clinical trial data and guidelines.
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