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Updated: May 6, 2026
Primary Culture of Human Vestibular Schwannomas
Published on: July 20, 2014
Schwannomas, benign tumors with a senescent phenotype
S Simonetti1, C Serrano2, J Hernández-Losa1
1Pathology Department, Hospital Universitari Vall d'Hebron, and Universitat Autonoma de Barcelona, Barcelona, Spain.
Background:
Schwannomas are benign nerve sheath tumors that only very rarely undergo malignant changes. Oncogenic-induced senescence is a defense mechanism against such malignant transformation. Different molecular pathways are involved in this process, such as RAS-RAF-MAPK. Based on the fact that the RAS-RAF-MAPK pathway is known to be activated in peripheral nerve sheath tumors, this study analyzes senescence markers in Schwannomas to demonstrate the possible role of senescence in their genesis.
Methods:
A retrospective immunohistochemical study was done in 39 schwannoma and 18 malignant peripheral nerve sheath tumors (MPNST). Staining for p16INK4a, Ki67, p53 and CyclinD1 was performed in all the cases. Additionally, β-galactosidase staining was done in those cases in which frozen tissue was available (n=8).
Results:
Higher levels of p16INK4a (p=0.0001) and lower levels of Ki67 (p=0.0001) were found in Schwannomas. Beta-galactosidase activity was positive in 5/5 Schwannomas and negative in 3/3 MPNST.
Conclusions:
Our results support the senescence nature of Schwannomas and the absence of a senescence phenotype in MPNST.
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