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Updated: May 6, 2026

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Published on: August 1, 2025
Hemospray treatment is effective for lower gastrointestinal bleeding
I Lisanne Holster1, Enric Brullet2, Ernst J Kuipers1
1Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands.
Hemospray effectively achieved initial hemostasis in lower gastrointestinal bleeding (LGIB). However, cautious use is advised for patients on antithrombotic therapy or with spurting bleeds due to rebleeding risks.
Area of Science:
- Gastroenterology
- Endoscopy
- Hemostasis
Background:
- Acute lower gastrointestinal bleeding (LGIB) presents diverse origins and necessitates urgent hemostasis.
- Hemospray, a novel hemostatic agent, shows promise for upper gastrointestinal bleeding (UGIB).
Purpose of the Study:
- To evaluate the feasibility and effectiveness of Hemospray in managing lower gastrointestinal bleeding (LGIB).
- To identify the optimal patient population for Hemospray in LGIB treatment.
Main Methods:
- Analysis of outcomes in nine consecutive patients with active LGIB treated with Hemospray.
- Data collected from two major European hospitals.
Main Results:
- Initial hemostasis was achieved in all nine patients following Hemospray application.
- Two patients (22%) experienced rebleeding, both on acetyl salicylic acid and presenting with spurting bleeds.
Conclusions:
- Hemospray demonstrates potential efficacy in managing LGIB.
- Cautious application of Hemospray is recommended for patients on antithrombotic therapy and those with spurting bleeds.
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