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Polyamines and programmed cell death.

Panagiotis N Moschou1, Kalliopi A Roubelakis-Angelakis

  • 1Department of Plant Biology and Forest Genetics, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, 75007 Uppsala, Sweden.

Journal of Experimental Botany
|November 13, 2013
PubMed
Summary
This summary is machine-generated.

Polyamines (PAs) are vital for survival but also regulate programmed cell death (PCD). This review explores how PAs directly and indirectly influence PCD pathways in animals and plants.

Keywords:
Apoptosisautophagycell cyclecell deathdevelopmentoxidasesoxidative stresspolyaminesprogrammed cell deathspermidine

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Area of Science:

  • Cell Biology
  • Biochemistry

Background:

  • Polyamines (PAs) are essential molecules for cellular functions.
  • Emerging evidence links PAs to programmed cell death (PCD) regulation.
  • PAs' role in PCD can be direct or indirect via metabolic products.

Purpose of the Study:

  • To review and compare the mechanisms of PA-dependent PCD in animals and plants.
  • To elucidate the direct and indirect roles of PAs in programmed cell death.

Main Methods:

  • Literature review and comparative analysis of existing studies.
  • Examination of PA metabolism and its relation to cell death pathways.

Main Results:

  • PAs directly associate with cellular components involved in PCD.
  • Metabolic derivatives of PAs, including cytotoxic products, actively participate in PCD.
  • The precise mechanisms of direct PA control over PCD pathways require further investigation.

Conclusions:

  • Polyamines play a dual role in cell survival and programmed cell death.
  • Understanding PA-mediated PCD is crucial for various biological processes.
  • Comparative insights from animals and plants can advance the field of PA research.