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Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb.

Ben Xu1, Steven M Hrycaj, Daniel C McIntyre

  • 1Department of Internal Medicine, Division of Molecular Medicine and Genetics, University of Michigan, Ann Arbor, MI 48109.

Proceedings of the National Academy of Sciences of the United States of America
|November 13, 2013
PubMed
Summary

Anterior Hox5 genes are crucial for proper forelimb development by repressing Sonic Hedgehog (Shh) expression. Loss of Hox5 genes leads to anterior limb defects due to Shh derepression, revealing novel roles in limb patterning.

Keywords:
anteroposterior limb patterninggene interactionslimb developmentmouse developmental geneticsorganogenesis

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