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Updated: May 6, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Room-temperature synthesis of trisubstituted allenylsilanes via regioselective C-H functionalization
Rong Zeng1, Shangze Wu, Chunling Fu
1Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University , Hangzhou 310027, Zhejiang, P. R. China.
Abstract:
A Rh(III)-catalyzed o-C-H bond functionalization-based allenylation reaction of allenylsilanes 2 with N-methoxybenzamides 1 affords poly-substituted allenylsilanes with a wide range of attractive functional groups in moderate to excellent yields under very mild conditions (20 °C, compatible with ambient air and moisture). Those products may be transformed to different products with attractive structural features. Careful mechanistic studies suggest the reaction proceeds via o-rhodation, regioselective insertion, and β-H elimination.
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