Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

Drugs Used in Lower Respiratory Disorders: Overview

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Allergen-specific immunotherapy at earlier stages of allergic respiratory diseases: a change is in the air!

Current opinion in allergy and clinical immunology·2026

Same author

ARIA-Italy managing allergic rhinitis and asthma in a changing world: The role of the Pharmacist.

The World Allergy Organization journal·2025

Same author

Extrafine formulation of beclomethasone dipropionate/formoterol fumarate/glycopyrronium bromide delivered via pressurized metered-dose inhaler in the treatment of asthma: a review.

Therapeutic advances in respiratory disease·2025

Same author

Background therapy in severe asthma on monoclonal antibody treatment in real life.

Respiratory medicine·2025

Same author

Eosinophilic esophagitis and inhalant antigens: Pointing out the roles of allergic rhinitis, immunotherapy and biologic treatment.

The World Allergy Organization journal·2024

Same author

RIAIT (Italian Registry of Allergen Immunotherapy): Protocol for a New Tool in a New Vision of Disease-Modifying Therapy for Allergists.

Journal of personalized medicine·2024

Search research articles

Related Experiment Video

Updated: May 6, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Specific immunotherapy in asthma: a comprehensive review.

Giovanni Passalacqua¹

¹Allergy and Respiratory Diseases, IRCCS San Martino, IST, University of Genoa , Genoa , Italy.

The Journal of Asthma : Official Journal of the Association for the Care of Asthma

|November 14, 2013

Summary

Allergen immunotherapy (SIT), including subcutaneous (SCIT) and sublingual (SLIT) forms, can improve asthma symptoms, especially when co-occurring with rhinitis. However, it is not recommended as a standalone treatment for asthma alone.

More Related Videos

Methodology for Sputum Induction and Laboratory Processing

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Related Experiment Videos

Last Updated: May 6, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Methodology for Sputum Induction and Laboratory Processing

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Area of Science:

Allergy and Immunology
Respiratory Medicine
Clinical Therapeutics

Background:

Allergen immunotherapy (SIT) for asthma lacks clear guideline recommendations, making its prescription a subject of ongoing debate.
Existing guidelines often do not provide definitive guidance on the use of SIT in asthma management.

Purpose of the Study:

To evaluate the efficacy and safety of allergen immunotherapy (SIT) in patients with asthma.
To determine the role of SIT in asthma management, particularly when associated with allergic rhinitis.

Main Methods:

An extensive review of the scientific literature was conducted.
Analysis included studies on both subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT).

Main Results:

Robust studies demonstrate that SCIT and SLIT improve asthma symptoms, particularly when asthma is linked with rhinitis.
Favorable meta-analyses exist, though trial heterogeneity limits their definitive conclusions.
Fatalities associated with SIT are rare, with no reported deaths in Europe in two decades or the US in four years. Uncontrolled asthma is a risk factor for adverse events, but SIT has not been shown to worsen or induce asthma.

Conclusions:

Sublingual immunotherapy (SLIT) and subcutaneous immunotherapy (SCIT) are viable options for asthma coexisting with rhinitis, provided asthma is well-controlled with medication.
A measurable clinical benefit in asthma symptoms can be anticipated in such cases.
SIT is not currently recommended as monotherapy for respiratory allergy presenting solely as asthma.