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Pulmonary function testing and chest tomography in patients with acromegaly
Gustavo Bittencourt Camilo, Fernando Silva Guimarães, Débora Pedroza Guedes Silva
1Postgraduate Programme in Medical Sciences, State University of Rio de Janeiro, Boulevard 28 de Setembro, 77, Vila Isabel, Rio de Janeiro 20551-030, Brazil. agnaldolopes.uerj@gmail.com.
Multidisciplinary Respiratory Medicine
|November 14, 2013
Summary
Acromegaly patients exhibit impaired lung function and structural changes, including small airway disease and air trapping. These respiratory abnormalities are not directly correlated with hormone levels in this study.
Area of Science:
- Pulmonology
- Endocrinology
- Radiology
Background:
- Acromegaly, a condition of excess growth hormone, is associated with increased respiratory disease mortality.
- Understanding lung abnormalities in acromegaly is crucial for patient management.
Purpose of the Study:
- To investigate lung structure and function abnormalities in acromegalic patients.
- To correlate these lung changes with hormonal levels.
Main Methods:
- Cross-sectional study comparing 20 acromegalic patients with 20 controls.
- Utilized spirometry, plethysmography, diffusing capacity, and respiratory muscle strength testing.
- High-resolution computed tomography (HRCT) was performed on acromegalic patients.
Main Results:
- Acromegalic patients demonstrated reduced respiratory muscle strength and increased airway resistance.
- HRCT revealed air trapping (60%), airway calcification (40%), and bronchiectasis (35%) in acromegalic patients.
- No significant correlation found between hormone levels and lung function or air trapping.
Conclusions:
- Acromegalic patients present with small airway disease and ventilation inhomogeneity.
- Air trapping in acromegaly is not explained by hormone levels or observed lung function changes.
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