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Novel glycosylated endomorphin-2 analog produces potent centrally-mediated antinociception in mice after peripheral

Jakub Fichna1, Marzena Mazur, Daria Grzywacz

  • 1Department of Biomolecular Chemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland; Department of Gastroenterological Surgery, Tenth People's Hospital of Shanghai, School of Medicine, Tongji University, Shanghai, China.

Bioorganic & Medicinal Chemistry Letters
|November 14, 2013
PubMed

Keywords:
1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate2-chloro-4,6-bis[3-(perfluorohexyl)propyloxy]-1,3,5-triazineAgOTfAntinociceptionBBBCDMTCNSDMFEM-2Endomorphin-2FmocGPI assayHATUHR-ESI-MSMOPN-(9-fluorenylmethyloxycarbonyl)NALMEO-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroboratePeripheral administrationRP HPLCTBTUTFAblood–brain barriercentral nervous systemdimethylformamideendomorphin-2guinea pig ileum assayhigh-resolution electrospray ionization mass spectrometryintravenousivnaloxone methiodidereversed-phase high-performance liquid chromatographysilver triflatetrifluoroacetic acidμ-opioid receptorμ-opioid receptor (MOP)

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