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Updated: May 6, 2026

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
Published on: January 27, 2010
[Pain during labour: sterile water injections?]
J C Hans van der Wouden1, Merle Geerdink
1VUmc, afd. Huisartsgeneeskunde en ouderengeneeskunde, Amsterdam.
Sterile water injections for labor pain are controversial. Two reviews of evidence reached different conclusions on their effectiveness, particularly regarding unplanned cesarean sections, highlighting the need for further research.
Area of Science:
- Obstetrics and Gynecology
- Pain Management
- Evidence-Based Medicine
Background:
- Dutch midwives began offering sterile water injections for labor pain in 2013.
- This initiative faced criticism from gynecologists and anesthesiologists due to insufficient evidence.
Purpose of the Study:
- To critically appraise existing literature on sterile water injections for labor pain.
- To resolve discrepancies between two recent systematic reviews on the intervention's efficacy.
Main Methods:
- Literature review focusing on two recent systematic reviews.
- Critical appraisal of randomized controlled trials included in the systematic reviews.
- Analysis of primary outcomes, specifically the rate of unplanned cesarean sections.
Main Results:
- Both systematic reviews analyzed largely overlapping randomized trials.
- Discrepancy noted in conclusions regarding unplanned cesarean sections, influenced by minor differences in included trials.
- Estimated effect size was similar, but statistical significance varied between reviews.
Conclusions:
- Conflicting conclusions from systematic reviews necessitate further investigation.
- Ongoing and planned trials are crucial to determine the role of sterile water injections in labor pain management guidelines.
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