Related Experiment Video

Updated: May 6, 2026

Back Mechanical Sensitivity Assessment in the Rat for Mechanistic Investigation of Chronic Back Pain
05:10

Back Mechanical Sensitivity Assessment in the Rat for Mechanistic Investigation of Chronic Back Pain

Published on: August 30, 2022

3.0K

Inflammatory pain pattern and pain with lumbar extension associated with Modic 1 changes on MRI: a prospective

F Bailly1, J-Y Maigne, S Genevay

  • 1Department of Rheumatology, Groupe Hospitalier Pitié-Salpétrière, Paris, France, baillyflorian@yahoo.fr.

European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
|November 14, 2013
PubMed
Abstract

Insights

Patients with low back pain (LBP) and Modic 1 changes on MRI often experience inflammatory pain and pain with lumbar extension. These findings aid in understanding LBP characteristics associated with Modic changes.

Area of Science:

  • Orthopedics and Sports Medicine
  • Radiology
  • Pain Management

Background:

  • Modic changes on MRI are common findings in patients with low back pain (LBP).
  • The clinical significance of Modic 1 signal changes in LBP remains incompletely understood.
  • Differentiating clinical characteristics associated with Modic 1 changes can aid in diagnosis and treatment.

Purpose of the Study:

  • To compare the clinical features of patients with low back pain (LBP) who exhibit Modic 1 signal changes on MRI versus those without.
  • To identify specific clinical characteristics associated with Modic 1 changes in chronic non-specific LBP.

Main Methods:

  • A case-control study design was employed, including 120 patients with chronic non-specific LBP and recent MRI.
  • Patients were categorized into a Modic 1 group and an age- and gender-matched control group.
  • Data collection involved questionnaires and physical examinations to assess pain patterns (including inflammatory indicators), and lumbar range of motion. Statistical analyses included univariate and multivariate methods.

Main Results:

  • Modic 1 patients demonstrated a significantly higher prevalence of an inflammatory pain pattern (p = 0.006) and worse pain with lumbar extension (p < 0.005).
  • A better response to oral steroids was observed in the Modic 1 group (p = 0.004).
  • Multivariate analysis identified sedentary work, pain with lumbar extension, and an inflammatory pain pattern as significant predictors associated with Modic 1 changes.

Conclusions:

  • Clinical characteristics indicative of Modic 1 changes in LBP include an inflammatory pain pattern and pain experienced during lumbar extension.
  • These findings suggest that Modic 1 changes on MRI may be linked to specific pain mechanisms in LBP patients.
  • Further research could explore targeted therapeutic strategies based on these identified clinical associations.

More Related Videos

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation04:42

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

Published on: June 26, 2018

14.2K
Biomechanical Changes Related to Low Back Pain: An Innovative Tool for Movement Pattern Assessment and Treatment Evaluation in Rehabilitation06:28

Biomechanical Changes Related to Low Back Pain: An Innovative Tool for Movement Pattern Assessment and Treatment Evaluation in Rehabilitation

Published on: December 13, 2024

1.8K

Related Concept Videos

Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
34
Herniated Intervertebral Disc l: Introduction01:29

Herniated Intervertebral Disc l: Introduction

Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
44