Related Experiment Video
Updated: May 6, 2026

Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
Radiation therapy for stage IVA cervical cancer
Naoya Murakami1, Takahiro Kasamatsu, Madoka Morota
1Department of Radiation Oncology, National Cancer Center Hospital, 5-1-1, Tsukiji Chuo-ku, Tokyo 104-0045, Japan. namuraka@ncc.go.jp.
Background:
To evaluate the outcome and discover predictive factors for patients with stage IVA cervical cancer treated with definitive radiation therapy.
Patients And Methods:
We retrospectively reviewed 34 patients with stage IVA cervical cancer who received definitive radiation therapy between 1992 and 2009.
Results:
On univariate analysis, statistically significant prognostic factors for improved local control rate (LCR) were absence of pyometra (p=0.037) and equivalent dose in 2 Gy fractions (EQD2) at point A greater than 60 Gy (p=0.023). Prognostic factors for improved progression-free survival (PFS) were absence of pelvic lymph node metastasis at initial presentation (p=0.014), and EQD2 at point A greater than 60 Gy (p=0.023).
Conclusion:
Patients with stage IVA disease had poor median survival. However adequate radiation dose to point A produced favorable LCR and PFS, therefore efforts should be made to increase the point A dose.
Related Concept Videos
Tumor Immunotherapy
Radiation: Applications
The average...
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

