Related Experiment Video
Updated: May 6, 2026
11:56
Visualization of the Axonal Projection Pattern of Embryonic Motor Neurons in Drosophila
Published on: June 16, 2017
7.3K
Semaphorin7A: branching beyond axonal guidance and into immunity
Ramon Garcia-Areas1, Stephania Libreros, Vijaya Iragavarapu-Charyulu
1Department of Biomedical Sciences, Charles E. Schmidt College of Medicine, Florida Atlantic University, 777 Glades Road, Boca Raton, FL, 33431-0991, USA.
Immunologic Research
|November 14, 2013
Summary
Semaphorin7A (SEMA7A) regulates immune responses beyond its known role in nerve guidance. This review explores SEMA7A's function in immunity, inflammation, and cancer.
Area of Science:
- Immunology
- Neurobiology
- Molecular Biology
Background:
- Semaphorins are proteins initially identified for axonal guidance.
- Semaphorins have diverse physiological roles, including immune system regulation.
- Semaphorin7A (SEMA7A) is a key regulator of immune responses.
Purpose of the Study:
- To review the structure and function of Semaphorin7A (SEMA7A).
- To discuss SEMA7A's role in innate and adaptive immunity.
- To explore SEMA7A's involvement in inflammatory diseases and cancer.
Main Methods:
- Literature review of studies on Semaphorin7A.
- Analysis of SEMA7A's molecular structure and function.
- Examination of SEMA7A's immunological and pathological roles.
Main Results:
- SEMA7A plays a significant role in modulating immune responses.
- SEMA7A is implicated in both innate and adaptive immunity.
- SEMA7A is involved in the pathogenesis of inflammatory diseases and cancer.
Conclusions:
- SEMA7A is a multifunctional protein with critical roles in immunity.
- Understanding SEMA7A's function offers insights into inflammatory diseases and cancer.
- Further research into SEMA7A could reveal therapeutic targets.
Related Concept Videos
01:31Immunoglobulin-like Cell Adhesion Molecules
3.3K
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
3.3K
01:22Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
1.8K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
1.8K
01:21Chemotaxis and Direction of Cell Migration
5.0K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
5.0K
01:02Role of Septins
1.5K
Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
1.5K
01:31Mechanism of Lamellipodia Formation
3.1K
Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
3.1K
01:39Mechanism of Filopodia Formation
2.5K
Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
2.5K