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Related Experiment Video

Updated: May 6, 2026

The Submerged Printing of Cells onto a Modified Surface Using a Continuous Flow Microspotter
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Single-cell printer: automated, on demand, and label free.

Andre Gross1, Jonas Schöndube, Sonja Niekrawitz

  • 11Laboratory for MEMS Applications, Department of Microsystems Engineering (IMTEK), University of Freiburg, Freiburg, Germany.

Journal of Laboratory Automation
|November 14, 2013
PubMed
Summary

This study introduces an automated inkjet-like system for printing single living cells. The technology achieves high printing efficiency and cell viability, enabling advanced single-cell analysis for biological applications.

Keywords:
label freepiezoelectric printingsingle cellssingle-cell analysissingle-cell microarrays

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Area of Science:

  • Cell Biology
  • Biotechnology
  • Microfluidics

Background:

  • Single-cell analysis is crucial for understanding cellular functions beyond bulk population studies.
  • Engineering approaches are vital for isolating and analyzing individual cells.
  • Previous research developed inkjet-like printing for single cells.

Purpose of the Study:

  • To present characterization results of a fully automated prototype instrument for noncontact single living cell printing.
  • To demonstrate the system's capability for biological and biomedical applications.

Main Methods:

  • Utilized a transparent microfluidic drop-on-demand dispenser chip.
  • Integrated a camera-assisted automatic detection system for cell classification.
  • Employed a noncontact inkjet-like printing method for single-cell deposition.

Main Results:

  • Achieved printing efficiencies greater than 80%.
  • Maintained cell viability rates of approximately 90%.
  • Successfully demonstrated printing of single-bead and cell arrays, and single-cell deposition/culture in microwell plates.

Conclusions:

  • The automated prototype instrument is suitable for single-cell printing and analysis.
  • The technology enables precise deposition and culture of individual cells.
  • This advancement supports diverse biological and biomedical research applications.