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Site-specific engineering of chemical functionalities on the surface of live hepatitis D virus

Shixian Lin1, Huan Yan, Lin Li

  • 1Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871 (China).

Angewandte Chemie (International Ed. in English)
|November 14, 2013
PubMed
Abstract

No abstract available in PubMed .

Keywords:
click chemistryhepatitis D virussite-specific engineeringunnatural amino acids

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Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
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