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Author Spotlight: Advanced Ex Vivo Model for Investigating Cancer-Adipose Microenvironment Interaction

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Peritoneal carcinomatosis.

Federico Coccolini¹, Federico Gheza, Marco Lotti

¹Federico Coccolini, Marco Lotti, Luca Ansaloni, Department of General Surgery, Papa Giovanni XXIII Hospital, 24127 Bergamo, Italy.

World Journal of Gastroenterology

|November 14, 2013

Summary

This summary is machine-generated.

Peritoneal carcinomatosis (PC) is a loco-regional disease. Multimodal treatments combining cytoreductive surgery and chemotherapy show promise for improving survival in patients with gastrointestinal cancer.

Keywords:

Advanced Cancer Carcinosis Colorectal Cytoreductive surgery Gastric Hipec Intraperitoneal chemotherapy Ovarian Peritoneal

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Murine Experimental Model of Original Tumor Development and Peritoneal Metastasis via Orthotopic Inoculation with Ovarian Carcinoma Cells

Murine Experimental Model of Original Tumor Development and Peritoneal Metastasis via Orthotopic Inoculation with Ovarian Carcinoma Cells

Published on: December 9, 2016

Area of Science:

Oncology
Surgical Oncology
Gastroenterology

Background:

Peritoneal carcinomatosis (PC) is a common complication of gastrointestinal and gynecological cancers.
PC significantly reduces survival rates in patients with advanced cancer.
Recent understanding highlights PC as a loco-regional disease, amenable to targeted treatment.

Purpose of the Study:

To review the evidence on treating peritoneal carcinomatosis across various tumor types.
To emphasize the importance of a multidisciplinary approach for optimal loco-regional control.
To guide clinicians in providing effective treatment strategies for PC.

Main Methods:

Systematic review of literature on multimodal treatment for PC.
Analysis of studies combining cytoreductive surgery, intraperitoneal hyperthermic chemotherapy, and systemic chemotherapy.
Evaluation of treatment outcomes focusing on loco-regional control and survival.

Main Results:

Multimodal therapy, including cytoreductive surgery and hyperthermic chemotherapy, offers promising outcomes for PC.
Aggressive surgical and chemotherapeutic approaches can improve loco-regional disease control.
Optimal treatment selection is crucial for enhancing patient survival.

Conclusions:

Peritoneal carcinomatosis can be effectively managed as a loco-regional disease.
Multimodal treatment strategies are essential for improving outcomes in PC patients.
Further research and multidisciplinary collaboration are key to advancing PC treatment.