A rare case of Pacinian corpuscle neuroma

Area of Science:

• Neuropathology
• Surgical Oncology

Background:

• Pacinian corpuscle neuromas are rare tumors arising from specialized nerve endings.
• Digital and palmar pain of unknown etiology can be challenging to diagnose.

Observation:

• An elderly woman presented with severe digital pain attributed to thumb osteoarthritis.
• Subtle clinical signs were noted, and the pain resolved completely after tumor excision.

Findings:

• The case highlights a Pacinian corpuscle neuroma as a cause of severe digital pain.
• Histological examination and presenting features of these rare tumors are discussed.
• Pacinian corpuscle hyperplasia is suggested as a differential diagnosis for digital pain.

Implications:

• This case underscores the importance of considering rare nerve tumors in the differential diagnosis of persistent digital pain.
• Accurate diagnosis and surgical management can lead to complete pain resolution.
• Further research into Pacinian corpuscle abnormalities may improve diagnostic strategies for digital pain.