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Related Concept Videos

MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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Abnormal Proliferation02:23

Abnormal Proliferation

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Related Experiment Video

Updated: May 6, 2026

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR
08:30

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR

Published on: May 16, 2012

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MicroRNAs in prostate cancer.

Won Tae Kim1, Wun-Jae Kim

  • 1Department of Urology, Chungbuk National University College of Medicine, Cheongju, Korea.

Prostate International
|November 14, 2013
PubMed
Summary

MicroRNAs (miRNAs) are small RNAs regulating gene expression. This review assesses tissue and circulating miRNAs as diagnostic and prognostic markers for prostate cancer, highlighting their therapeutic potential.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are small, noncoding RNAs regulating gene expression posttranscriptionally.
  • miRNA expression profiles are altered in cancer tissues and linked to clinicopathological parameters.
  • Both tissue-derived and circulating miRNAs show potential as cancer biomarkers.

Purpose of the Study:

  • To review and assess the utility of tissue-derived and circulating miRNAs.
  • To evaluate miRNAs as diagnostic and prognostic markers for prostate cancer.
  • To explore the therapeutic potential of miRNAs in prostate cancer.

Main Methods:

  • Literature review and assessment of existing studies on miRNAs in prostate cancer.
  • Analysis of miRNA expression profiles in relation to cancer diagnosis and prognosis.
Keywords:
Biological markersMicroRNAsProstatic neoplasms

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  • Evaluation of miRNA alterations in association with clinicopathological parameters.

    • Main Results:

    • Altered miRNA expression is associated with prostate cancer development and progression.
    • Tissue and circulating miRNAs show promise for predicting cancer recurrence and patient survival.
    • Specific miRNAs may serve as valuable diagnostic and prognostic indicators for prostate cancer.

    Conclusions:

    • Tissue and circulating miRNAs are promising biomarkers for prostate cancer diagnosis and prognosis.
    • Further research into miRNA-based diagnostics and therapeutics for prostate cancer is warranted.
    • miRNAs hold potential for improving patient outcomes in prostate cancer management.