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Myocardial perfusion defects in patients with chronic hepatitis B infection

Shigeo Maruyama1, Masahiko Koda, Yoshikazu Murawaki

  • 1Maruyama Medical Clinic, Hamada, Japan.

Journal of Gastroenterology and Hepatology
|November 15, 2013
PubMed

Insights

Chronic hepatitis B infection is linked to myocardial injury, with 47% of patients showing perfusion defects. Treatment with interferon improved these defects, correlating with reduced hepatitis B virus (HBV) levels and IgG.

Area of Science:

  • Cardiology
  • Hepatology
  • Infectious Diseases

Background:

  • The relationship between hepatitis B virus (HBV) infection and myocardial injury is not well understood.
  • Chronic HBV infection may affect cardiac health.

Purpose of the Study:

  • To investigate myocardial conditions in patients with chronic HBV infection.
  • To assess the impact of interferon therapy on myocardial perfusion in these patients.

Main Methods:

  • 47 patients with chronic hepatitis B underwent ECG, echocardiography, cardiac biomarkers, and thallium-201 myocardial scintigraphy.
  • Myocardial perfusion defects were quantified using a severity score (SS).
  • 10 patients were followed before and after interferon (IFN) therapy.

Main Results:

  • 47% of chronic hepatitis B patients exhibited myocardial perfusion defects (abnormal SS).
  • Higher pretreatment SS correlated with HBV DNA titer and IgG levels.
  • IFN therapy significantly reduced SS in responders, linked to decreased IgG.

Conclusions:

  • Myocardial perfusion defects are prevalent in chronic HBV patients.
  • IFN therapy can improve cardiac perfusion in HBV infection, associated with viral load reduction and decreased IgG levels.
Abstract

Keywords:
hepatitis B virusinterferon therapymyocardial injurythallium-201 myocardial scintigraphy

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