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Quantitative MRI analysis in children with multiple sclerosis: a multicenter feasibility pilot study.

Tanuja Chitnis, Charles R Guttmann, Alexander Zaitsev

    BMC Neurology
    |November 15, 2013
    PubMed
    Summary

    Multicenter MRI studies in pediatric multiple sclerosis (MS) are feasible. Quantitative lesion volume (LV) analysis revealed differences in lesion load among demographic groups, highlighting the need for further research in pediatric MS.

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    Area of Science:

    • Neurology
    • Radiology
    • Pediatrics

    Background:

    • Pediatric multiple sclerosis (MS) is a rare but impactful neurological disorder.
    • Quantitative MRI offers valuable insights into MS, but multicenter studies are crucial due to small patient numbers.

    Purpose of the Study:

    • To demonstrate the feasibility of a multicenter approach for assessing pediatric MS.
    • To evaluate lesion volume (LV) characteristics in a collaborative cohort of children with MS.

    Main Methods:

    • Implemented standardized MRI scanning protocols across six U.S. pediatric MS centers.
    • Analyzed T2 lesion number, T2-lesion volume (LV), individual lesion size, and gadolinium-enhancing lesion characteristics in 53-55 pediatric MS patients.
    • Utilized regression analyses to examine MRI measures in relation to demographic factors, controlling for disease and treatment duration.

    Main Results:

    • Mean T2 lesion count was 24.30 ± 19.68; mean enhancing lesion count was 1.85 ± 5.84.
    • Non-white subjects exhibited significantly higher T2-lesion volume (LV) and maximal individual T2-LV compared to white patients.
    • A trend suggested larger mean lesion size in males than females.

    Conclusions:

    • Assessing MRI lesion volume characteristics is feasible in a multicenter pediatric MS cohort.
    • Quantitative MRI metrics can reveal demographic-based differences in disease burden in pediatric MS.