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Related Concept Videos

Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

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Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid...
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Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...
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Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
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Infectious diseases arise from intricate interactions between pathogens and their reservoirs. A reservoir of infection refers to the natural habitat where a pathogen lives, grows, and multiplies, serving as a continual source of infection. Reservoirs are broadly classified as either living or nonliving, and each plays a unique role in disease transmission, significantly influencing public health interventions and control strategies.Humans act as reservoirs for a wide array of pathogens,...
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Colonisation of Pathogens01:25

Colonisation of Pathogens

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Pathogen colonization of host tissues is a critical step in the development of infectious diseases. Various pathogenic microorganisms, including bacteria, fungi, viruses, and protozoa, have evolved complex strategies to attach to, invade, and persist within host environments. These mechanisms enable pathogens to establish infections, evade immune responses, and resist antimicrobial treatments.Attachment to Host CellsIn bacteria, colonization typically begins with adherence to host epithelial...
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Infection01:20

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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Related Experiment Video

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Author Spotlight: Development of an Enhanced Protocol for Rapid and Accurate Isolation of Campylobacter from Food Products
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Waterborne transmission ofCampylobacter enteritis.

D N Taylor1, M Brown, K T McDermott

  • 1Enteric Diseases Branch, Division of Bacterial Diseases, Center for Infectious Diseases, Centers for Disease Control, 30333, Atlanta, Georgia, USA.

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Campylobacter jejuni, a common cause of diarrhea, can be traced from animals to humans. Improved environmental sampling techniques now allow for the detection of this pathogen in water sources, aiding in understanding disease transmission.

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Area of Science:

  • Microbiology
  • Environmental Health
  • Epidemiology

Background:

  • Campylobacter jejuni is a significant global cause of diarrheal illness.
  • A large animal reservoir, including domestic animals, contributes to C. jejuni transmission.
  • Previous limitations in environmental sampling and strain differentiation hindered tracing transmission pathways.

Purpose of the Study:

  • To investigate the feasibility of environmental sampling for Campylobacter jejuni.
  • To explore the role of waterborne transmission in C. jejuni-related illnesses.
  • To improve understanding of Campylobacter jejuni transmission dynamics from animals to humans.

Main Methods:

  • Environmental sampling of surface water and animal populations in wilderness and community settings.
  • Isolation and serotyping of Campylobacter jejuni from environmental and human samples.
  • Epidemiological investigation of water-related disease outbreaks.

Main Results:

  • Campylobacter jejuni was identified as a cause of sporadic diarrheal disease in hikers, linked to untreated surface water consumption.
  • Environmental isolates of C. jejuni, including from mountain streams and animals, were found to be serotypically identical to human strains.
  • A community outbreak of Campylobacter enteritis was epidemiologically associated with the public water system, with C. jejuni isolated from water sources.

Conclusions:

  • Recent advancements enable the environmental isolation of Campylobacter jejuni.
  • Waterborne transmission is a significant route for Campylobacter jejuni in both wilderness and community settings.
  • Improved detection methods enhance the ability to understand and track C. jejuni disease transmission.