Diclofenac and naproxen analysis by microbore liquid chromatography (LC) with native fluorescence detection
W R Baeyens1, G van der Weken, M Schelkens
1Laboratory of Drug Quality Control, Department of Pharmaceutical Analysis, Faculty of Pharmaceutical Sciences, University of Ghent, Pharmaceutical Institute, Harelbekestraat 72, B-9000, Ghent, Belgium.
Abstract:
A microbore LC system applying native fluorescence detection is described for analysis of the nonsteroidal antiinflammatory agents diclofenac and naproxen in pharmaceutical preparations, allowing the visualization of some diclofenac decomposition products. The suggested system is practical and specific and offers detection limits of 0.2 Μg ml(-1) for diclofenac and of 1 pg ml(-1) for naproxen (solutions to be injected). Moreover, the solvent consumption is reduced by a 10-fold factor compared to the classical HPLC setup.
More Related Videos
09:24Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
Published on: August 22, 2017
13:35A Convenient Method for Extraction and Analysis with High-Pressure Liquid Chromatography of Catecholamine Neurotransmitters and Their Metabolites
Published on: March 1, 2018
Related Concept Videos
Therapeutic Drug Monitoring: Drug Analysis Methods
High-Performance Liquid Chromatography: Types of Detectors
