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Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
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Jejunal stricture in a premature infant: Is cytomegalovirus the causative pathogen or a superinfection?

Aysel Unlüsoy Aksu1, Sinan Sarı, Ramazan Karabulut

  • 1Department of Pediatric Gastroenterology, Gazi University School of Medicine, Ankara, Turkey.

The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology
|November 15, 2013
PubMed

Insights

Cytomegalovirus infection can cause gastrointestinal issues in premature infants. This case highlights cytomegalovirus enteritis and jejunal stricture in a preterm neonate, confirmed by histopathology.

Area of Science:

  • Neonatal Medicine
  • Gastroenterology
  • Virology

Background:

  • Cytomegalovirus (CMV) infection commonly affects immunocompromised individuals and premature infants, often manifesting as gastrointestinal disease.
  • However, gastrointestinal involvement during the neonatal period is considered infrequent.
  • Previous literature describes neonatal gastrointestinal CMV infections primarily as necrotizing enterocolitis-like illnesses.

Observation:

  • A rare case of cytomegalovirus enteritis and jejunal stricture in a preterm neonate is presented.
  • Diagnosis was confirmed through histopathological examination of surgical specimens revealing characteristic CMV inclusion bodies.
  • This presentation is distinct from previously reported necrotizing enterocolitis-like presentations.

Findings:

  • The study presents a confirmed case of cytomegalovirus enteritis leading to jejunal stricture in a preterm neonate.
  • Histopathology was crucial in identifying cytomegalovirus inclusion bodies as the cause.
  • This case contributes to understanding CMV's direct role in neonatal gastrointestinal pathology.

Implications:

  • This case underscores the importance of considering cytomegalovirus as a direct causative agent of gastrointestinal disease in preterm neonates, beyond its association with necrotizing enterocolitis.
  • Accurate diagnosis through histopathology is vital for appropriate management.
  • Further research is needed to differentiate primary CMV enteritis from secondary CMV infection in the context of necrotizing enterocolitis.

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