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Sample Handling

Sample Handling

Transportation of samples from the collection point to the laboratory, as well as storage and preservation techniques, are crucial for maintaining sample integrity and ensuring accurate and reliable test results.
Samples should be transported carefully from collection points to the laboratory. They should be properly sealed and clearly labeled to prevent cross-contamination. To preserve the sample integrity, optimal temperature conditions during transport are essential. This could involve using...

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Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Published on: November 30, 2022

Veterinary and human biobanking practices: enhancing molecular sample integrity.

G Hostetter¹, E Collins, P Varlan

¹Van Andel Research Institute, 333 Bostwick Avenue NE, Grand Rapids, MI 49503, USA.

Veterinary Pathology

|November 15, 2013

Summary

This study introduces methods to assess tissue sample integrity using RNA integrity number and protein analysis. These techniques ensure reliable genomic data for research and biobanking applications.

Keywords:

anatomic pathology biorepository digital imaging genomics spectral imaging tissue sample quality assurance/quality control

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Biobanking of Human Aqueous and Vitreous Liquid Biopsies for Molecular Analyses

Biobanking of Human Aqueous and Vitreous Liquid Biopsies for Molecular Analyses

Published on: September 11, 2023

Area of Science:

Biospecimen Science
Genomics
Pathophysiology

Background:

Animal models are crucial for understanding disease in veterinary and human medicine.
Advancements in genomic sequencing necessitate robust methods for tissue sample analysis.
Biospecimen science and biobanking are vital for maintaining sample integrity and ensuring reproducible research.

Purpose of the Study:

To integrate protein expression, RNA integrity, and morphological analysis for assessing tissue sample quality.
To predict the impact of pre-analytical variables on tissue integrity.
To establish standardized methods for tissue collection and processing.

Main Methods:

Utilized animal experiments with murine kidney tissues.
Combined microscopy-based protein expression analysis with RNA integrity number (RIN) analysis.
Quantified morphological changes due to autolysis and employed digital imaging.

Main Results:

Developed methods to predict RNA integrity based on morphological and protein analyses.
Demonstrated that genomic methods complement traditional in vivo imaging for biospecimen science.
Established reliable measures of biospecimen integrity for time points up to 3 hours post-resection.

Conclusions:

Integrative analysis of molecular and morphological data enhances biospecimen integrity assessment.
Standardized tissue processing protocols are essential for accurate genomic data.
This approach supports translational research by ensuring the quality of biological samples.