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Related Experiment Video

Updated: May 6, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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Cardiovascular magnetization transfer ratio imaging compared with histology: a postmortem study.

Hendrikus J A Crooijmans1, Thomas D Ruder, Wolf-Dieter Zech

  • 1Department of Radiology, Division of Radiological Physics, University of Basel Hospital, Basel, Switzerland.

Journal of Magnetic Resonance Imaging : JMRI
|November 15, 2013
PubMed
Summary

Cardiovascular magnetization transfer ratio (MTR) imaging accurately detects myocardial microstructural changes. MTR imaging successfully differentiates scar tissue and acute myocardial infarction from normal tissue, correlating well with histology.

Keywords:
histologymagnetization transfer ratiomyocardial infarctsteady state free-precessionvirtopsy

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Area of Science:

  • Cardiovascular Imaging
  • Medical Physics
  • Histopathology

Background:

  • Cardiovascular magnetization transfer ratio (MTR) imaging assesses myocardial microstructure.
  • Steady-state free precession is a promising MTR imaging technique.
  • Histological analysis is the gold standard for myocardial tissue characterization.

Purpose of the Study:

  • To correlate cardiovascular MTR imaging findings with histological analysis in postmortem cases.
  • To evaluate MTR imaging's ability to differentiate myocardial pathologies.

Main Methods:

  • Three postmortem cases with suspected myocardial infarction were studied.
  • Cardiovascular MTR and T2-weighted (T2w) imaging were performed.
  • Tissue abnormalities were identified and MTR values compared to normal tissue.

Main Results:

  • Elevated MTR values (up to 20%) correlated with fibrous scar tissue.
  • Reduced MTR values (up to 20%) indicated edema or inflammatory infiltration.
  • MTR imaging distinguished normal myocardium, scar, and acute infarction, outperforming T2w imaging.

Conclusions:

  • Cardiovascular MTR imaging effectively detects microstructural myocardial changes.
  • MTR imaging provides accurate differentiation of myocardial infarction, scar, and edema.
  • MTR imaging shows superior diagnostic performance compared to T2w imaging for myocardial pathologies.