Related Experiment Video
Updated: May 6, 2026
08:22
Assessment and Characterization of Hyaloid Vessels in Mice
Published on: May 15, 2019
8.8K
Defective bone microstructure in hydronephrotic mice: a histomorphometric study in ICR/Mlac-hydro mice
Panan Suntornsaratoon1, Kannikar Wongdee, Wacharaporn Tiyasatkulkovit
1Center of Calcium and Bone Research (COCAB), Faculty of Science, Mahidol University, Thailand; Department of Physiology, Faculty of Science, Mahidol University, Thailand.
Anatomical Record (Hoboken, N.J. : 2007)
|November 15, 2013
Summary
Mice with hydronephrosis (kidney swelling) showed significant bone loss and reduced bone strength. This bone deterioration was linked to decreased bone formation and resorption, suggesting a new model for studying kidney disease-related bone conditions.
Area of Science:
- Nephrology
- Bone Biology
- Genetics
Background:
- Chronic kidney disease is linked to bone problems.
- The relationship between hydronephrosis and bone loss is not well understood.
Purpose of the Study:
- To investigate microstructural bone changes in mice with spontaneous hydronephrosis.
- To utilize computer-assisted bone histomorphometry for detailed analysis.
Main Methods:
- Studied Imprinting Control Region (ICR) mice with a mutation causing bilateral nonobstructive hydronephrosis (ICR/Mlac-hydro).
- Employed computer-assisted bone histomorphometry to analyze bone microarchitecture and turnover.
- Compared ICR/Mlac-hydro mice with wild-type littermates.
Main Results:
- ICR/Mlac-hydro mice exhibited reduced trabecular bone volume, number, and thickness, with increased separation.
- Bone resorption and formation markers (eroded surface, osteoclast surface, osteoblast surface) were significantly lower in ICR/Mlac-hydro mice.
- Decreased moment of inertia indicated reduced bone strength in the hydronephrotic mice.
Conclusions:
- ICR/Mlac-hydro mice display trabecular bone loss due to decreased osteoblast and osteoclast activity, indicating low bone turnover.
- This mouse model is valuable for studying bone disease associated with hydronephrosis.
