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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Updated: May 6, 2026

Merkel Cell Polyomavirus Infection and Detection

Merkel Cell Polyomavirus Infection and Detection

Published on: February 7, 2019

Digital Merkel cell carcinoma.

Alanna M Rebecca¹, Randall O Craft, Anthony A Smith

¹Mayo Clinic Scottsdale, Arizona, USA.

The Canadian Journal of Plastic Surgery = Journal Canadien De Chirurgie Plastique

|November 15, 2013

Summary

This summary is machine-generated.

Merkel cell carcinoma (MCC), a rare skin cancer, is increasing annually. Early diagnosis and tailored treatment combining surgery, radiation, and chemotherapy are crucial for this aggressive neuroendocrine tumour.

Keywords:

Hand tumour Merkel cell carcinoma Ray amputation

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Area of Science:

Dermatology
Oncology
Pathology

Background:

Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer.
Recent data shows an 8% annual increase in age-adjusted MCC rates over 15 years.

Observation:

MCC typically appears as a painless, rapidly growing, solitary red or purple skin nodule.
Diagnosis is frequently delayed due to MCC's rarity, often requiring histopathological confirmation.

Findings:

Definitive MCC diagnosis utilizes specific immunohistochemical markers: positive for anticytokeratin-20 and negative for thyroid transcription factor-1.
Current treatment strategies integrate surgery, radiation, and chemotherapy, as definitive Phase III trial data is lacking.

Implications:

The rising incidence of MCC necessitates increased awareness and diagnostic vigilance.
Individualized treatment approaches are essential for managing this aggressive skin neoplasm.