Related Experiment Video
Updated: May 6, 2026

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
[Study on bioequivalence of new Wubei fast-release tablet]
Hu Chen1, Sheng-Bin Gao, Li-Juan Li
1Department of Pharmacy, Hebei Chemical and Pharmaceutical College, Shijiazhuang 050026, China. chenhuisjz@126.com
Objective:
To prepare a new Wubei fast-release tablet and study the pharmacokinetics and bioequivalence of self-prepared Wubei fast-release tablet and Wubei powder in Beagle dogs.
Method:
Wubei fast-release tablet was prepared with direct powder compression. Six Beagle dogs were randomly devided into two groups. They were orally administered with Wubei fast-release tablet and Wubei powder, respectively. Peimine concentrations in human plasma were determined by HPLC-MS/MS after administration. The pharmacokinetic parameters were calculated by DAS 2.0 using a non-compartmental analysis. The bioequivalence of fast-release tablet and powder was evaluated.
Result:
The main pharmacokinetic parameters of peimine in Wubei fast-release tablet as follows: Cmax (7.4 +/- 2.3) microg x L(-1), AUC(0-t) (59.13 +/- 15.25) microg x L(-1) x h(-1), Tmax (1.5 +/- 0.0) h. The main pharmacokinetic parameters of peimine in Wubei powder as follows: Cmax (8.0 +/- 1.7) microg x L(-1), AUC(0-t) (68.78 +/- 16.27) microg x L(-1) x h(-1), Tmax (1.5 +/- 0.0) h. The 90% confidence interval of InAUC(0-t), and lnCmax of peimine in Wubei fast-release tablet were 95.4% - 104.6%, 90.9% - 109.1% of corresponding parameters of Wubei powder, respectively.
Conclusion:
The self-prepared Wubei fast-release tablet and Wubei powder were bioequivalent. And the self-prepared Wubei fast-release tablet had simple production process, easy administration.
Related Concept Videos
Bioequivalence studies: Biowaivers
Modified-Release Drug Delivery Systems: Bioavailability
Bioequivalence: Overview
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules
Drug Dissolution: Requirements and Profile Comparison
Bioequivalence of Drugs: Drugs with Multiple Indications

